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Medical Management : For patients with documented osteoporosis or high fracture risk, pharmacologic bone-protective therapy may be indicated regardless of GLP-1 use

The key signaling pathways associated with oxidative stress in asthma include the Nrf2, NFB, mitochondrial, MAPK, thioredoxin-1, and aldose reductase pathways

Functional and phenotypic analyses confirm the induction of a pancreatic endocrine fate, including positive dithizone (DTZ) staining indicative of insulin production, as well as the upregulation of key pancreatic markers such as Nestin , PDX-1 , paired box gene 4 ( PAX4 ), neurogenin 3 ( NGN3 ), Isl-1, MAFA, insulin, and glucose transporter 2 ( GLUT2 )

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