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In these very high-risk patients, GLP-1 receptor agonists reduce overall mortality, with an NNT of 42 (95% CI, 29 to 84) over five years

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Glucagon-like peptide 1 agonists, also known as GLP-1s, are a type of medicine used to treat diabetes and can also help with weight loss, according to the Mayo Clinic

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The mechanism involves water retention affecting nerve pathways

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