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Furthermore, in 3-month-old transgenic 5xFAD mice, liraglutide reduced astrocyte activation and A deposition while increasing levels of insulin-degrading enzyme (IDE) [52]
Researchers soon realized that mimicking the action of GLP-1 could offer a promising approach to diabetes treatment
5,6 However, mortality is not correlated with BMI, and weight loss is not correlated with improved health even in patients with diabetes and cardiovascular disease
Instead, they continuously buffer cells against entering a runaway peroxidative state and help preserve membrane integrity under sublethal oxidative stress
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