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Metabolic remodeling in pulmonary artery smooth muscle cells (PASMCs) and pulmonary artery endothelial cells (PAECs), including enhanced glycolysis and mitochondrial dysfunction, provides the energy and material basis for abnormal proliferation of vascular cells (Xu et al., 2024

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The substantial weight reduction observed with tirzepatide monotherapy (15-21% body weight in clinical trials) suggests that any perceived benefits likely reflect tirzepatide's pharmacological effects rather than synergistic action

SRC-3 is required for prostate cancer cell proliferation and survival