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Statistical analysis A sample size of 300 participants provided an effective power of at least 96% for the two co-primary endpoints, and at least 43% for all confirmatory secondary endpoints, which were tested in a predefined hierarchical order (Supplementary Table 4)
In clinical trials, tirzepatide has demonstrated a positive impact on lipid profiles, including reductions in total cholesterol and low-density lipoprotein cholesterol (LDL-C), often referred to as bad cholesterol
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