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GLP-1 receptor agonists were originally developed to treat diabetes, but they are being used more and more to help obese and overweight patients lose weight

But the data pipelines that would enable that kind of outcomes measurement connecting prescription fill data, lab trends, weight trajectories, and downstream utilization across plan years largely do not exist in integrated form

The tripeptide has a donor-atom arrangement that binds copper(II) with high affinity under physiological conditions, and once that was appreciated it became clear that most of the reported activity tracked the complex rather than the free ligand