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The upper limit (UL) for vitamin C is 3000 mg, based on gastrointestinal tolerance rather than toxicity

TB-500 provides complementary anti-inflammatory activity through multiple mechanisms including direct inhibition of NF-B signaling, modulation of immune cell phenotypes, and promotion of inflammatory resolution

TNF- is found at high levels in the synovium of patients with RA [234], while IL-1 is recognized as a major contributor to inflammation in the disease [235]