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Sitagliptin works ONLY when blood sugar is elevated, to address diminished insulin levels due to -cell dysfunction and uncontrolled production of glucose by the liver (due to pancreatic -cell and -cell dysfunction) Figure
With respect to the previously mentioned study, this proof-of concept study has important methodological strengths residing in the availability of baseline and post-treatment hepatic biopsies
For each measure, absolute and percentage change from index to 6 months were reported
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