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Sudden Blindness (NAION) Condition: NAION (eye stroke) Risk Increase: 1.32x to 4.28x higher than other drugs Onset: Sudden, painless, irreversible MDL Status: New separate MDL 3163 created Description: Stroke of the optic nerve causing permanent partial or total blindness in one eye What It Is: Nonarteritic anterior ischemic optic neuropathy (NAION) occurs when blood flow to the optic nerve is disrupted or cut off

A 2,700-person study out of Denmark saw an average of 16% body weight loss at 64 weeks for the 20% of the participants who remained at microdose levels for the duration of the study