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Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol
Strain W303-1b/F with higher synthetic capacity of GSH was chosen as the starting strain for further introduction of other biosynthetic pathways
But at the end of the day, it's still a low grade toxin that you're putting inside the body
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