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Finally, FGF21 reduces expression and activation of the NLRP3 inflammasome in vascular endothelial cells in diabetic mice (184), which both protects the cells themselves and reduces further inflammatory damage by suppressing pyroptosis and immune cell recruitment (185)
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10.12659/aot.884013 18 ChenL.LanZ
To overcome these limitations, combination strategies are under active exploration
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