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Some patients participate for 6 months to a year, while others may need ongoing support for maintenance
1-10 mg/kg in animal studies KPV studies: 100 micromolar oral concentrations in colitis models
Uncommon and rare adverse effects include cystitis, folliculitis, gastrointestinal infections, hypersensitivity reactions, changes in appetite, depression, insomnia, balance disorders, lethargy, restless leg syndrome, syncope, photophobia, presbyopia, tinnitus, confusion, palpitations, hypertension, hypercholesterolaemia, and weight gain
Some people need a short course close together, while others may only need occasional top-ups for maintenance
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