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Arthralgia and myalgia are hallmark lupus symptoms, and distinguishing medication-related musculoskeletal complaints from disease activity requires careful clinical assessment

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this was usually achieved by replacing alanine in the second position with another amino acid other than proline

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Changes in actin polymerization status can affect focal adhesion signaling complexes, integrin-mediated signaling, and transcriptional responses that govern cellular movement and structural adaptation

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