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The results indicated a clear dose-response effect: Mean weight loss was 21% at 7.2 mg , compared to 17.5% at 2.4 mg, and much lower with placebo
In humans, the CYP450 enzyme that predominately catalyses the formation of NAPQI is CYP2E1, although in vitro CYP3A4, CYP2D6 and CYP1A2 have also been implicated in the formation of the toxic metabolite [18,19,20]
The risk of muscle and bone loss is real, but with proper resistance training programming and clinical oversight, we can mitigate those risks while you achieve your weight goals
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