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Before beginning any large-scale study, a patch test is essential to rule out sensitivity or irritation, particularly from the azelaic acid

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Safety Considerations As with any compounded sterile injectable, prescribers should screen patients before administration: G6PD deficiency: Patients with known or suspected G6PD deficiency should be evaluated carefully, as IV glutathione and related sulfhydryl compounds have been associated with hemolysis in this population

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