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For example, oral semaglutide (Rybelsus) must be taken on an empty stomach with a small amount of water, waiting 30 minutes before eating, drinking, or taking other medications

In contrast, treatment with the GLP-1 receptor agonist liraglutide yielded a small improvement in kidney function at the end of the follow-up period [89], and in two large-scale trials, the use of SGLT2 inhibitors was accompanied by a meaningful and durable improvement in glomerular function and a reduction in the risk of serious adverse renal events [56, 58]

Meaningful improvements are possible across a range of doses

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