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"Semaglutide or Tirzepatide and Optic Nerve and Visual Pathway Disorders in Type 2 Diabetes." JAMA Netw Open

In the only reported trial to date involving people with AUD who actively wished to reduce or cease drinking, a once-weekly GLP-1 agonist called exenatide did not result, in the overall group, in a reduction of the number of heavy drinking days, but the drug did enable those with AUD and obesity to do so

GLP-1R activation also inhibits NF-B activation through the cAMP/PKA signaling pathway, suppressing inflammatory and angiogenic gene expression in retinal cells, including VEGF

Tirzepatide may lower blood pressure largely because of weight loss and improved metabolic function