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However, factors like stress, aging, and toxins can deplete its levels
This metabolic adaptation can be relevant in triple-negative breast cancers (those lacking ERs, PRs and HER2, which constitute approximately a quarter of breast tumours) that express xCT, which exhibit increased levels of ROS induced by decreased glutamate levels upon glutamine scarcity
In addition to catalyzing this major CoQ 10 -reducing reaction, complex I pumps protons into the intermembrane space, generating a proton motive force that drives ATP synthesis 68,70
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