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The development of novel techniques for ultra-sensitive -synuclein detection, particularly real-time quaking-induced conversion [108], could improve the accuracy of identifying prodromal PD and serve as reliable biomarkers for treatment response
The crystal structure of human GPx3 revealed that each subunit contained a selenocysteine (Sec) residue and the active Sec-53 was located in a pocket on the protein surface with Gln-87, Trp-161 and Asn-162 nearby 13 , which formed a catalytic tetrad highly conserved in the selenium-dependent GPx family 14
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