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WOMAC pain score improved by 4.5 points

The side effects were most commonly gastrointestinal, with 16.7% on the lowest dose up to 100% on the highest dose with no serious adverse events [62]

In the SURMOUNT-1 trial, tirzepatide produced mean weight reductions of 19.5% and 20.9% at 72 weeks in the two highest study groups, compared with 3.1% with placebo under the treatment-regimen analysis