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doi: 10.1074/jbc.M704165200 42 MakotoK-O

In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver

By inhibiting NNMT, 5Amino1MQ Peptide reshapes the metabolic phenotype of adipose tissue, promotes lipolysis, increases energy expenditure, and restores dynamic balance of fat metabolism - one of its core weightloss mechanisms