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While cyanocobalamin has proved effective in preventing vitamin B12 deficiency, there is increasing evidence that the coenzyme B12 forms have a distinct advantage and better spectrum of action in many specialised applications
Large doses may trigger hormonal changes or alter skin bacteria, leading to pimples or worsening of existing acne
Macro-B12 is commonly defined as the fraction of B12 removed by precipitation with polyethylene glycol (PEG)
No reconstitution is required
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