Primäres Offenwinkelglaukom und Primäre Linsenluxation (POAG/PLL) - Shar Pei Hundebesitzer Dog is heterozygous for “masked”

Dog is heterozygous for “masked” locus

Affected dogs show signs of uncoordinated movements

only pheomelanin is produced

Because production of eumelanin is disabled

Primäres Offenwinkelglaukom und Primäre Linsenluxation (POAG/PLL) - Shar Pei Hundebesitzer Dog is heterozygous for “masked”Primary open angle glaucoma (POAG) and primary lens luxation (PLL) are two different diseases in Shar pei that are caused by the same mutation. Primary open angle glaucoma (POAG) is a disease characterized by increased intraocular pressure, which causes retinal and optic disk destruction. As the pressure in the eye increases, the eyeball increases in size and becomes painful. If POAG is left untreated, increased pressure in the eye leads to optic